Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study | BMC Medicine | Full Text
Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study | BMC Medicine | Full Text
Tag: aging
Fructose Could Drive Alzheimer’s Disease – Neuroscience News
Foraging requires focus, rapid assessment, impulsivity, exploratory behavior and risk taking. It is enhanced by blocking whatever gets in the way, like recent memories and attention to time. Fructose, a kind of sugar, helps damp down these centers, allowing more focus on food gathering.
In fact, the researchers found the entire foraging response was set in motion by the metabolism of fructose whether it was eaten or produced in the body. Metabolizing fructose and its byproduct, intracellular uric acid, was critical to the survival of both humans and animals.
The researchers noted that fructose reduces blood flow to the brain’s cerebral cortex involved in self-control, as well as the hippocampus and thalamus. Meanwhile, blood flow increased around the visual cortex associated with food reward. All of this stimulated the foraging response.
Fructose Could Drive Alzheimer’s Disease – Neuroscience News
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease | Nature Aging
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease | Nature Aging
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease | Nature Aging
The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial | Heart
The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial | Heart
The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial | Heart
Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network
Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network
Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network
We once refused to talk about cancer.
We now “politely” ignore mental changes with age.
If you have worked in social services with older people, this study confirms what you have always seen. And you can see cognitive changes with older family and friends.
You will see a lot of writing about prevention and treatment. Those have good use. But leave out too many people.
We need accommodation. We have lots of aging people with mental changes. Lots of them. We need better lives for them.
We live in a culture that has recently come to strongly favor recalling details and procedures.
The “cognitive load” of daily activities, both essential and pleasing, has increased greatly in a generation.
To use a cliche, where once snapshots would have arrived in the mail, it was a Kodak ad, we now expect grandma to get online and use social media to see photos of the grandchildren.
Don’t dismiss the cliche. Feeling connected is essential, and becomes much harder in our culture that isolates the older.
Ordering food or groceries for delivery now requires using the app or website.
Etc
So far, the always inadequate response has sent underpaid and understaffed humans to help humans use a human built system the aging humans cannot use well.
Dumb. We use inadequate staffing to ameliorate the problems of automation. Dumb.
Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment | Scientific Reports
Comparisons of the AD portrait to a recent depression portrait revealed a high congruence of downregulated genes in both.
Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment | Scientific Reports
In the label ‘adult failure to thrive,’ medicine reveals its own failures – STAT
In the label ‘adult failure to thrive,’ medicine reveals its own failures – STAT
In the label ‘adult failure to thrive,’ medicine reveals its own failures – STAT
Trends in Diet Quality Among Older US Adults From 2001 to 2018 | Lifestyle Behaviors | JAMA Network Open | JAMA Network
Trends in Diet Quality Among Older US Adults From 2001 to 2018 | Lifestyle Behaviors | JAMA Network Open | JAMA Network
Trends in Diet Quality Among Older US Adults From 2001 to 2018 | Lifestyle Behaviors | JAMA Network Open | JAMA Network
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study – Fiorito – – Aging Cell – Wiley Online Library
DAMA study is intentionally based on non-extreme interventions, meaning that relatively easily achievable changes in one’s lifestyle behaviors lead to a significant slowing down of biological aging biomarkers, which in turn are associated with higher longevity, lower risk of developing age-related diseases, and increased quality of life in the older age. Further, our results indicate that dietary quality and physical activity influence epigenetic aging through complementary molecular mechanisms, suggesting that their effect is potentially cumulative rather than interchangeable.
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