fasting slows muscle repair both immediately after the conclusion of fasting as well as after multiple days of refeeding. We show that ketosis, either endogenously produced during fasting or a ketogenic diet or exogenously administered, promotes a deep quiescent state in muscle stem cells (MuSCs).Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling: Cell Metabolism
Trends in Diet Quality Among Older US Adults From 2001 to 2018 | Lifestyle Behaviors | JAMA Network Open | JAMA NetworkTrends in Diet Quality Among Older US Adults From 2001 to 2018 | Lifestyle Behaviors | JAMA Network Open | JAMA Network
We have widespread ill health. And in the US 42% of us have become obese. PE didn’t help most people.
Entertainment, porn, and sports show us buff physiques to consume. We prominently reward athletes. And advertising sells us convenient food.
We train people to external direction. Our received ideals of fitness come from military preparedness. And we measure and praise performance. Why?
Ill health increases. And the fitness industry grows. This is not working. This fitness does not help most people.
We are going to spend too much time sitting. We are going to look at screens a lot. How do we teach ways of moving as lifelong harm reduction?
We must teach hope because without it everything else we can teach won’t get used.Continue reading Toward a useful physical education
Objective: Major depressive disorder is the leading cause of disability worldwide. Yet, there remain significant challenges in predicting new cases of major depression and devising strategies to prevent the disorder. An important first step in this process is identifying risk factors for the incidence of major depression. There is accumulating biological evidence linking insulin resistance, another highly prevalent condition, and depressive disorders. The objectives of this study were to examine whether three surrogate measures of insulin resistance (high triglyceride-HDL [high-density lipoprotein] ratio; prediabetes, as indicated by fasting plasma glucose level; and high central adiposity, as measured by waist circumference) at the time of study enrollment were associated with an increased rate of incident major depressive disorder over a 9-year follow-up period and to assess whether the new onset of these surrogate measures during the first 2 years after study enrollment was predictive of incident major depressive disorder during the subsequent follow-up period. Methods: The Netherlands Study of Depression and Anxiety (NESDA) is a multisite longitudinal study of the course and consequences of depressive and anxiety disorders in adults. The study population comprised 601 NESDA participants (18–65 years old) without a lifetime history of depression or anxiety disorders. The study’s outcome was incident major depressive disorder, defined using DSM-IV criteria. Exposure measures included triglyceride-HDL ratio, fasting plasma glucose level, and waist circumference. Results: Fourteen percent of the sample developed major depressive disorder during follow-up. Cox proportional hazards models indicated that higher triglyceride-HDL ratio was positively associated with an increased risk for incident major depression (hazard ratio=1.89, 95% CI=1.15, 3.11), as were higher fasting plasma glucose levels (hazard ratio=1.37, 95% CI=1.05, 1.77) and higher waist circumference (hazard ratio=1.11 95% CI=1.01, 1.21). The development of prediabetes in the 2-year period after study enrollment was positively associated with incident major depressive disorder (hazard ratio=2.66, 95% CI=1.13, 6.27). The development of high triglyceride-HDL ratio and high central adiposity (cut-point ≥100 cm) in the same period was not associated with incident major depression. Conclusions: Three surrogate measures of insulin resistance positively predicted incident major depressive disorder in a 9-year follow-up period among adults with no history of depression or anxiety disorder. In addition, the development of prediabetes between enrollment and the 2-year study visit was positively associated with incident major depressive disorder. These findings may have utility for evaluating the risk for the development of major depression among patients with insulin resistance or metabolic pathology.
DAMA study is intentionally based on non-extreme interventions, meaning that relatively easily achievable changes in one’s lifestyle behaviors lead to a significant slowing down of biological aging biomarkers, which in turn are associated with higher longevity, lower risk of developing age-related diseases, and increased quality of life in the older age. Further, our results indicate that dietary quality and physical activity influence epigenetic aging through complementary molecular mechanisms, suggesting that their effect is potentially cumulative rather than interchangeable.
This report describes BMI increases among children aged 2–19 years during the COVID-19 pandemic.
the rate of body mass index (BMI) increase approximately doubled
Original Article from The New England Journal of Medicine — Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
This study does suggest that trying to persuade obese children to lose weight by exercising more is likely to be ineffective….
Our results suggest that adiposity is a better predictor of PA and sedentary behavior changes than the other way around.
Source: Fatness predicts decreased physical activity and increased sedentary time, but not vice versa: support from a longitudinal study in 8- to 11-year-old children | International Journal of Obesity