“The fructose survival hypothesis for obesity” – 24 July 2023, Philosophical Transactions of the Royal Society B
https://royalsocietypublishing.org/doi/10.1098/rstb.2022.0230
https://doi.org/10.1098/rstb.2022.0230
Summary
Obesity and its associated metabolic diseases have had devastating health consequences on modern society. Here, we link these diseases with the activation of a major survival pathway developed in nature to help animals prepare for times of scarcity. Unfortunately, we have unknowingly adopted the foods that activate this switch in our everyday diet, and coupled with the thrifty genes we picked up, we are now suffering the consequences of putting this survival pathway in overdrive. The tragedy of our success is even greater than thought, for newer studies suggest that the fructose pathway may also increase our risk for cancer, pregnancy-related disease and neurological disorders. We recommend proceeding with studies such as outlined above to better understand the role of fructose metabolism in health and disease.
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